Preparation and Application of Photo Cross-Linked Nanase Dextran Hydrogels
The methacrylated dextran(Dex-MA)with photo cross-linked property was prepared by grafting glycidyl methacrylate(GMA)onto dextran(Dex)via an ester exchange reaction.Curcumin(Cur)was loaded in the framework of zeolitic imidazolate framework material(ZIF-8)by"one-pot"method,and then the pH-responsive ZIF-8@Cur was synthesized directly.The photo cross-linked hydrogels(Dex-ZC)with good mechanical and antibacterial properties were prepared by introducing ZIF-8@Cur nanase into Dex-MA solution,adding photo initiator I2959 and initiating photo crosslinking through ultraviolet irradiation.The structure and morphology of Dex-MA,ZIF-8@Cur and Dex-ZC were analyzed by nuclear magnetic resonance hydrogen spectrum,ultraviolet absorption spectrum,Fourier infrared spectroscopy,X-ray diffraction and scanning electron microscope.The mechanical properties and antibacterial properties of Dex-ZC were studied by tensile test and bacteriostatic ring test.Results showed that the release rate of ZIF-8@Cur was faster in acidic environment,and the cumulative release amount of Cur reached(72.98±0.18)% within 24 h.Dex-ZC hydrogel had compact porous structure and good mechanical properties,which was caused by the addition of ZIF-8@Cur.The bacteriostatic ring test showed that the addition of positive charge ZIF-8@Cur made Dex-ZC hydrogel have excellent antibacterial activity against E.coli and S.aureus.This study provided more possibilities for the development of photo cross-linked hydrogel dressings on wound healing.
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