Preparation of Semi-Interpenetrating Polymer Network Hydrogel of Sodium Alginate/Polylactic Acid and Its Property
In order to improve the loading and release activity of sodium alginate, hydrophobic modification to alginate was made by mixing alginate with polyactic acid and NaCl/CaCl_2 solution to forms a semi-interpenetrating polymer network. The swelling property and pH sensitivity of the hydrogel was studied as well as the embedment and controlled release experiments were carried out. The effects of mass and loading amount on the controlled release were studied. The modified microsphere of alginate hydrogel has increased the loading amount and improved controlled release property of the drug Ibuprofen.
Sodium AlgenateModification of Hydrophobic PropertyControlled Release
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万方数据
维普
