摘要
糖尿病是因胰岛素分泌不足、血糖水平增高而导致的代谢疾病.肽作为一种生物活性物质可参与生物体内复杂的生理活性反应,调节细胞功能活动.且肽具有储量丰富、毒副作用小、分子量小、作用靶点明确、易吸收等优点.因此,肽可作为一种新的降糖药物被开发利用.针对肽的分离纯化方法(包括膜分离法、色谱法、电泳法等)进行了总结,并对肽在降糖活性方面的研究进行综述,以期为开发降糖新药提供参考依据.
Abstract
Diabetes is a kind of metabolic disease caused by the lack of insulin and high blood glucose level.Peptide,as a bioactive substance,can participate in complex physiological reactions in organisms and regulate cellular functional activities.Peptide has the advantages of abundant reserves,hypotoxicity,low molecular weight,clear target and easily absorption,which can be used as a new hypoglycemic drug for development and utilization.The techniques for separation and purification of peptide(including membrane separation,chromatography,electrophoresis,etc.)were summarized.In addition,the research on hypoglycemic activity of peptide was also introduced to provide references for the development of new hypoglycemic drug.
基金项目
黑龙江省省属高等学校基本科研业务费科研项目(145209304)
齐齐哈尔大学大学生创新创业训练计划项目(x202310232010)
维普
万方数据