Regulatory role of the E2F transcription factor family in adipogenesis
E2F transcription factors(E2Fs)are the main target proteins of the retinoblastoma protein(pRb,RB or RB1)family.As a key family member of the transcription factor,E2Fs play a crucial role in regulating the transcription,DNA synthesis and cell cycle of downstream genes.In recent years studies on adipogenic have shown that multiple members of the E2F family are involved in the regulation of adipogenic production.Reviewdthe regulatory role of E2Fs in adipogenesis,including the structural characteristics of E2Fs family members and the mechanism of action in adipogenesis.It was found that E2F-1 and E2F-3 had the function of promoting adipogenesis in mammals,and E2F-2 may be involved in the differentiation process of bovine preadipocytes,but the specific function is still unclear,while E2F-4 and E2F-5 are inhibitors of adipogenesis and play an inhibiting role in adipogenesis in mammals,while the role of E2F-6,E2F-7 and E2F-8 in the regulation of adipogenesis is not clear.Reviewd the regulatory role of E2Fs in fat proliferation and differentiation,and discusses the therapeutic strategy of E2Fs as a target for obesity,so as to provide a theoretical basis for the subsequent prevention and treatment of obesity and related diseases.
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维普
