The general chemistry course is a compulsory course for students majoring in food science,animal science,animal medicine,and agriculture in agricultural and forestry universities in the first semester of university.In order to assist students in successfully completing the construction of university and even lifelong learning models,the online and offline integrated interactive teaching mode will fully integrate the advantages of online and offline teaching modes,and promote the coordinated development of students'knowledge,abilities,and comprehensive literacy.Through teaching resource and processes design,the teaching mode will ensure that the online and offline multi-channel interactive teaching is completed in the three stages of before,during and after the class to complete the online and offline multi-channel interactive teaching,through the leadership-teaching-learning-feedback-enhancement-higher-order leadership of the closed-loop teaching mode to complete the entire teaching process,and urge students to complete the transformation from passive learning to active learning.Teaching practice has shown that this teaching mode enriches the teaching means,which is conducive to improving the teaching efficiency and teaching effect,and is also more conducive to stimulating students'learning enthusiasm and cultivating their ability of independent learning and lifelong learning.