Experimental study on extraction and purification process of low grade copper sulfate produced by a copper smel-ting plant. A mixed extraction system single factor extraction experiment was conducted,and under the optimal process con-ditions,the extraction rates of impurity elements in the crude copper sulfate solution reached Fe 99.99%,Zn 99.99%,Al 90.60%,Ca 54.74%,As 97.91%,Bi 99.95%,and Si 3.51%;After recrystallization,the residual solution can further re-duce Ni content and produce copper sulfate products that meet the"Industrial Copper Sulfate"( HG/T 5215-2017) premi-um standard.