Comparative Studies on Uric acid-lowering,Anti-inflammatory,and Purgative Effects of Different Varieties of Dahuang
To compare uric acid(UA)-lowering,anti-inflammatory,and purgative effects of different varieties of Dahuang(rhubarb,Rhei Radix et Rhizoma).Methods:All 90 Wistar rats of similar body mass were selected,and prepared into the models with acute hyperuricaemia via hypoxanthine and potassium oxonate,foot swelling models were established through the application of carrageenan gum,constipation models were built up via compound diphenoxylate,and they were given aqueous extract of rhubarb for medicinal use(Rheum officinale Baill.),Zhangye rhubarb(Rheum palmatum L.)and Tangut rhubarb(Rheum tanguticum Maxim.ex Balf.)in high dose(5 g/kg)and low dose(1.25 g/kg),a blank group,negative control group and positive control group were also set up in the experiment.To survey uric acid-lowering effects by detecting UA in the blood of rats,to explore anti-inflammatory effects by observing rat foot swelling and measuring the contents of total protein in foot tissue fluid,and to investigate the purgative effects by observing the time of first dark stool within six hours,total number of dark stool,and the contents and activity of colon Na+-K+-ATP enzyme.Results:Rhubarb could significantly lower the levels of UA,ranking in the order of effects:Zhangye rhubarb,rhubarb for medicinal use and Tangut rhubarb,and there was a significant difference(P<0.05);rhubarb owns certain anti-inflammatory effects,ranking in the order of effects:Tangut rhubarb,Zhangye rhubarb and rhubarb for medicinal use,the differences existed between three kinds of rhubarb(P<0.05);rhubarb possesses purgative effects,and it ranked in the sequences:Tangut rhubarb,Zhangye rhubarb and rhubarb for medicinal use,noticeable differences existed between three kinds of rhubarb(P<0.05).Conclusion:Aqueous extract of rhubarb has stronger effects of lowering UA,resisting inflammation and purgative effects,certain differences exist in pharmaceutical effects between different varieties of rhubarbs,and it should be differentiated in clinical practice.
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NSTL
万方数据
维普
