首页|基于正交实验优化中药配方颗粒调剂工艺

基于正交实验优化中药配方颗粒调剂工艺

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目的:探讨影响中药配方颗粒药品下药量因素,优化最佳配药、储存条件,保证患者用药安全、有效,提高患者对中药配方颗粒药品的满意度.方法:通过正交实验法优化最佳配药、储存条件,对中药配方颗粒进行质量监管.结果:配方颗粒调剂工艺的影响因素依次为:湿度>粒径>温度;最佳调剂工艺为温度21℃,湿度45%,粒径为全部通过2号筛且不通过3号筛.结论:温度、湿度、粒径三者对配方颗粒的调剂工艺都有显著影响,依据本实验所得最佳配药条件,能达到最准确配药量.
The Optimization of the Preparation of Chinese Medicine Formula Granules Based on Orthogonal Experiment
Objective:To explore the factors that affects the dosage of Chinese medicine formula granules,optimize the best dispensing and storage conditions,ensure the safety and effectiveness of the patients'medication,and improve the patients'satisfaction with Chinese medicine formula granules.Methods:The dispensing and storage conditions were optimized by orthogonal experiment,the quality of Chinese medicine formula granules were supervised,in order to obtain drugs of qualified quality.Results:The influencing factors of the preparation of Chinese medicine formula granules were humidity>the diameter of the granules>temperature;the best preparation technology was a temperature of 21℃,a humidity of 45%and the diameter of the granules could pass through the sieve No.2,and not through the sieve No.3.Conclusion:Temperature,humidity and the diameter of the granules have significant influence on the preparation of Chinese medicine formula granules,and the optimal dosing conditions obtained in the experiment could achieve the most accurate dosage.

Chinese medicine formula granulesorthogonal experimentdosagedispensing process

王婷婷、李先文、马琴国、张露

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甘肃省中医院,甘肃 兰州 730050

中药配方颗粒 正交实验 下药量 调剂工艺

甘肃省中药质量与标准研究重点实验室开放基金资助项目

ZYZL16-008

2024

西部中医药
甘肃中医药研究院

西部中医药

CSTPCD
影响因子:0.98
ISSN:1004-6852
年,卷(期):2024.37(1)
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