Research Progress of Traditional Chinese Medicine Prevention and Therapy for Bronchial Asthma Based on TGF-β1/Smads Signal Pathway
Nowadays,many experimental studies revealed that TGF-β1 has developed the effects in pathological foundation of airway inflammation and airway remodeling in the pathogenesis of asthma.TGF-β1 has dual effects on airway inflammation,it could not only induce the airway inflammation through stimulating eosinophilia,but also inhibit airway inflammation by stimulating the generation of mast cells;in addition,TGF-β1 could promote fibroblast growth and cause airway remodeling since it has a superb fibrogenic effect.TCM could intervene the attacks of asthma and relieve clinical symptoms of asthma through regulating TGF-β1/smads signal pathway.The paper reviewed research progress of the influence of TGF-β1/Smads signal pathway on bronchial asthma and TCM intervention effects,hoping to provide the thinking for the prevention and the treatment of bronchial asthma by TCM.
bronchial asthmaTGF-β1/Smads signal pathwayTCMreview
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