Research Progress of the Effect of HIF-1α on Vascular Calcification in Chronic Kidney Disease
On the foundation of the characteristics and mechanism of vascular calcification in cardiovascular disease(CVD),the paper summed up the close relationship between HIF-1α and vascular calcification(VC)in CVD patients,CVD is the leading fatal complication of chronic kidney disease(CKD),approximately occupying 50%of total mortality rate in CKD patients.VC as the primary cause of CVD is positively correlated with the progress of renal function.Hypoxia is an important factor in promoting osteoblast-like transdifferentiation and calcification of vascular smooth muscle cells(VSMCs)in CKD patients,however,hypoxia-inducible factor-1α(HIF-1α)is a key transcriptional regulatory factor in cell hypoxia response,it could not only promote osteoblast-like differentiation of VSMCs and participate in the formation of VC by mediating a variety of osteogenic markers,but also take part in the attack and development of VC through inducing inflammation and oxidative stress,participating in glycolytic pathway as well as inducing cellular apoptosis and autophagy.
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