Observation on Effects of Xubishu Tang Combined with Leflunomide in the Treatment of Rheumatoid Arthritis of Cold Dampness Obstruction Pattern
Objective:To discuss clinical effects of Xubishu Tang and leflunomide in the treatment of rheumatoid arthritis(RA)of cold dampness obstruction pattern.Methods:All 120 RA patients were separated into the observation group and the control group using random number table method,the control group was treated by leflunomide,and the observation group by Xubishu Tang and leflunomide,to compare clinical effects,main symptoms and body signs,the indicators of humoral immunity including ESR,RF,CRP and IgG,WHOQOL scores and the incidences of adverse reaction between both groups.Results:Total effective rate of the observation group was 91.67%(55/60),higher than 76.67%(46/60)of the control group(P<0.05);after the treatment,rest pain score,morning stiffness time,number of swollen joints and number of joint tenderness of the observation group were lower than these of the control group,average grip strength of both hands higher than that of the control group(P<0.05);after the treatment,the levels of ESR,RF,CRP and IgG of the observation group were lower than these of the control group(P<0.05);after the treatment,the scores of surroundings,physical health,social relationships,mental health of WHOQOL-BREF of the observation group were higher than these of the control group(P<0.05);the incidence of adverse reaction of the observation group was 6.67%(4/60),lower than 21.67%(13/60)of the control group(P<0.05).Conclusion:Compared with single use of leflunomide,its combination with Xubishu Tang could obviously improve clinical symptoms,body signs and the indicators of humoral immunity in RA patients,help improve the patients'clinical effects and quality of life,with low incidence of adverse reaction.
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