首页|基于卵巢颗粒细胞功能探讨调周法治疗卵巢储备功能减退的临床研究

基于卵巢颗粒细胞功能探讨调周法治疗卵巢储备功能减退的临床研究

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目的:基于卵巢颗粒细胞功能探讨中医药调周法对卵巢储备功能减退(diminished ovarian reserve,DOR)患者体内抗穆勒氏管激素(anti-mullerian hormone,AMH)水平的影响及临床疗效.方法:对60例DOR肾虚证患者给予中医药调周法治疗,观察治疗前后患者血清性激素各项水平[AMH、雌二醇(estra-diol,E2)、黄体生成素(luteinizing hormone,LH)、卵泡刺激素(follicle stimulating hormone,FSH)]和临床疗效.结果:治疗前后E2、LH、FSH水平比较差异无统计学意义(P＞0.05);治疗后AMH水平较治疗前升高(P＜0.05),中医证候积分较治疗前减少(P＜0.05),总有效率为86.7%(52/60);治疗期间均无明显不良反应.结论:中药调周法通过提高AMH、FSH水平来提升DOR肾虚证患者卵巢储备功能,调整月经周期,增加月经量,改善临床症状.
Clinical Study on the Treatment of Diminished Ovarian Reserve by Regulating Cycle Based on the Function of Ovarian Granulosa Cells
Objective:To discuss the influence and clinical effects of TCM cycle-regulating method on the levels of anti-mullerian hormone(AMH)in patients with diminished ovarian reserve(DOR)on the foundation of the function of ovarian granulosa cells.Methods:Sixty DOR patients of renal deficiency pattern were treated by TCM cycle-regulating method,To observe the levels of serum sex hormones(E2,LH and FSH),clinical effects before and after the treatment.Results:The difference had no statistical meaning in the levels of E2,LH and FSH before and after the treatment(P>0.05);after the treatment,the levels of AMH were elevated compared with before the treatment(P<0.05),TCM syndrome integrals were reduced than before the treatment(P<0.05),total effective rate was 86.7%(52/60),no obvious adverse reaction occurred during therapeutic period.Conclusion:Conclusion:TCM cycle-regulating method could improve renal deficiency pattern DOR patients'ovarian reserve,regulate the menstrual cycle,increase menstrual flow and improve the patients'clinical symptoms possibly through increasing the levels of AMH and FSH.

renal deficiency patterndiminished ovarian reserveovarian granulosa cellscycle-regulating methodanti-mullerian hormone

李时雨、莫蕙、许家莹、陈赟

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澳门科技大学,澳门特别行政区 999078

南京中医药大学附属医院,江苏 南京 210000

肾虚证 卵巢储备功能 卵巢颗粒细胞 调周法 抗缪勒氏管激素

国家自然科学基金江苏省卫生计生委科研课题第三批江苏省名老中医傅友丰工作室项目南京中医药大学中医学优势学科教育教改研究课题

81574009Q201602Q201602

2024

10.12174/j.issn.2096-9600.2024.01.30

西部中医药
甘肃中医药研究院

西部中医药

CSTPCD
影响因子：0.98
ISSN：1004-6852
年,卷(期)：2024.37(1)
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