Objective:To provide experimental evidence for further exploration into the mechanism of Huixiang Zhizhu soup(HX-S)on the improvement of microecology in adhesive intestinal obstruction(AIO)by observing the effects of the decoction on serum endotoxin in AIO rats.Methods:Among 72 rats,12 were chosen as the normal group,and the remaining 60 were prepared into rat models with AIO,after successfully modeling,and randomized into sham operation group,the model group,low(1.13g/mL),moderate(2.25g/mL)and high(3.38g/mL)doses groups of HX-S with 12 in each group.Different groups were given the corresponding medicine for three days,blood was taken from the femoral artery 12 h after the last dose,the contents of serum endotoxin was detected in limulus amebocyte lysate test;rats were sacrificed by cervical dislocation,some adhesive tissues were taken for pathological examination.Results:Compared with the normal group,the contents of serum endotoxin were increased obviously in the model group(P＜0.01);compared with the model group,the contents of serum endotoxin were decreased remarkably in sham operation group and different doses groups of HX-S(P＜0.01).Pathological results displayed that intestinal wall morphology was recovered gradually and inflammation was relieved in different treatment groups.Conclusion:HX-S is effective in treating AIO,and its mechanism might be related to protecting intestinal microecology.
维普
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