Research Progress on the Intervention of Traditional Chinese Medicine on the Prevention and Treatment of Breast Cancer via PI3K/Akt/mTOR Signaling Pathway
As an important target for the treatment of breast cancer,the phosphatidylinositol-3 kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway can regulate cell proliferation,apoptosis,differentiation and invasion of cancer cells,participating in the occurrence and development of breast cancer.This article reviews the PI3K/Akt/mTOR signaling pathway and targeted drugs,the occurrence and development of breast cancer influnenced by promoting the production of vascular endothelial factor,enhancing cellular proliferation,inhibiting cellular apoptosis and promoting the secretion of inflammatory factors mediated by the signaling pathway,as well as TCM intervention on the proliferation,apoptosis and drug resistance of breast cancer cells via the signaling pathway,and it is designed to provide the reference for the research and development of therapeutic medicine for breast cancer.
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