中医药干预Wnt/β-catenin信号通路治疗激素性骨质疏松症的研究进展

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中文摘要：对Wnt/β-catenin信号通路与激素性骨质疏松症(glucocorticoid-induced osteoporosis,GIOP)相关性及中药单体、中药复方干预Wnt/β-catenin信号通路治疗GIOP的研究进行综述,指出当Wnt/β-catenin信号通路受到抑制时,骨形成减少的同时骨吸收增加,从而诱发GIOP;中药单体及复方通过调控Wnt/β-catenin信号通路抑制剂Dickkopf相关蛋白1(dickkopf related protein 1,DKK1)、组织蛋白酶K(cathepsin K,CTSK)、Wnt抑制因子1(Wnt inhibitory factor 1,WIF1)、糖原合成酶激酶3β(glycogen synthetase kinase-3β,GSK3β)、骨硬化蛋白(sclerostin protein,SOST)等表达水平,再次激活Wnt/β-catenin信号通路,从而达到防治GIOP的目的.因此,探讨中医药对Wnt/β-catenin信号通路的作用,可为防治GIOP提供有力依据,为中医药治疗GIOP提供新方向.

外文标题：Research Progress of the Treatment of Glucocorticoid-induced Osteoporosis with Traditional Chinese Medicine Intervention on Wnt/β-catenin Signaling Pathway

外文摘要：By reviewing the connections between Wnt/β-catenin signaling pathway and glucocorticoid induced osteoporosis(GIOP),and the researches on the treatment of GIOP with herbal monomers and herbal compounds intervention on Wnt/β-catenin signaling pathway,it is found that the inhibition of Wnt/β-catenin signaling pathway is related to the occurrence and development of GIOP;herbal monomers and herbal compounds could activate Wnt/β-catenin signaling pathway again by regulating the expressions of the inhibitors of Wnt/β-catenin signaling pathway including DKK1,CTSK,WIFI,GSK3β,SOST,thereby preventing and treating GIOP.Therefore,the exploration into the effects of TCM on Wnt/β-catenin signaling pathway could provide the powerful reference for the prevention and the treatment of GIOP and the new direction for TCM therapy of GIOP.

外文关键词：

osteoporosis,glucocorticoid-inducedWnt/β-catenin signaling pathwaytraditional Chinese medicine

作者：

史凡凡、赵继荣、雒永生、马同、陈文、蔡毅、张天龙、杨涛、张立存、李玮农、杨文通、蒋鹏

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作者单位：

甘肃中医药大学,甘肃兰州 730030

甘肃省中医院,甘肃兰州 730050

关键词：

骨质疏松症,激素性 Wnt/β-catenin信号通路中医药

基金：

国家自然科学基金甘肃省自然科学基金甘肃省中医药管理局科研课题甘肃省中医药管理局科研课题兰州市创新人才项目兰州市科技局科研课题甘肃中医药大学研究生创新基金项目

项目编号：

8176087717JR5RA051GZK-2018-35GZK-2019-22018-RC-992019-ZD-116CS2018-10

出版年：

2024

DOI：

10.12174/j.issn.2096-9600.2024.03.13

西部中医药

甘肃中医药研究院

西部中医药

CSTPCD

影响因子：0.98

ISSN：1004-6852

年,卷(期)：2024.37(3)

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