Clinical Observation of Modified Mufangji Tang Combined with Celecoxib in the Treatment of Damp-heat Pattern Acute Gouty Arthritis
Objective:To observe the curative effects of modified Mufangji Tang combined with celecoxib in the treatment of damp-heat pattern acute gouty arthritis and its influence on serum cyclooxygenase-2(COX-2),blood uric acid(BUA),erythrocyte sedimentation rate(ESR)and inflammatory factors.Methods:All 135 patients with acute gouty arthritis of damp-heat pattern were divided into the observation group,the control group No 1 and the control group No 2 in light of random number table method,with 45 cases in each group.The control group No 1 took celecoxib capsules orally,the control group No 2 were treated with celecoxib capsules and Simiao powder,the observation group were given celecoxib capsules and modified Mufangji Tang,the course of the treatment was 14 days.To observe clinical symptoms,total symptom score(TSS)and TCM syndrome integrals in three groups,and to detect the levels of COX-2,BUA,ESR,TNF-α,IL-8,IL-1β,IFN-γ,IL-18 and IL-4,and perform safety evaluation.Results:After the treatment,TSS and TCM syndrome integrals,the levels of serum BUA,ESR,COX-2,TNF-α,IL-1β and IL-8 of the observation group were lower than these of two control groups(P＜0.05),different indexes of the observation group and the control group No 2 were lower than these of the control group No 1(P＜0.05);the levels of IL-4,IL-18 and IFN-γ of the observation group were higher than these of the two control groups(P＜0.05),different indexes of the observation group and the control group No 2 were higher than these of the control group No 1(P＜0.05).Total effective rate of the observation group was 93.02%(40/43),higher than 73.17%(30/41)of the control group No 1(P＜0.05)and 83.33%(35/42)of the control group No 2(P＜0.05).After the treatment,there was no abnormal changes in the safety indexes of the three groups;the relapse rate of the observation group was lower than that of the two control groups(P＜0.05).Conclusion:Modified Mufangji Tang combined with celecoxib are superior to single Western medicine therapy and Simiao powder in combination with celecoxib in improving symptoms and body signs in patients,with low recurrence rate and high safety;and its mechanism might be related to reducing the levels of COX-2,BUA and ESR,and regulating the levels of inflammatory factors.
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