中医药干预NLRP3炎症小体治疗动脉粥样硬化的研究进展
Research Progress of TCM Intervention of NLRP3 Inflammasome in the Treatment of Atherosclerosis
陈晋玉 1雷瑗琳 2王南丁3
作者信息
- 1. 陕西中医药大学,陕西 咸阳 712046
- 2. 西安市中医医院,陕西 西安 710021
- 3. 陕西中医药大学,陕西 咸阳 712046;西安市中医医院,陕西 西安 710021
- 折叠
摘要
从中医药干预核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体入手,阐述中医药发挥抗炎的作用机理,认为NLRP3炎症小体参与的炎症反应贯穿动脉粥样硬化(atherosclerosis,AS)发展的全过程,其中清热药、活血药及补虚药在治疗AS中具有极大优势,为中医药治疗AS疾病提供新思路.
Abstract
Based on the intervention of traditional Chinese medicine on nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,the paper discussed the anti-inflammatory mechanism of traditional Chinese medicine.It is believed that inflammatory response involved in NLRP3 runs through the entire process of the development of atherosclerosis(AS).Among them,heat-clearing drugs,blood-activating drugs and deficiency-tonifying drugs have great advantages in the treatment of AS,providing new ideas for traditional Chinese medicine treatment of AS.
关键词
动脉粥样硬化/核苷酸结合寡聚化结构域样受体蛋白3/炎症小体/中医药Key words
atherosclerosis/nucleotide-binding oligomerized structural domain-like receptor protein 3/inflammasome/Chinese medicine引用本文复制引用
基金项目
国家自然科学基金项目(81503444)
陕西省自然科学基础研究计划(2020JQ-966)
西安市科协青年人才托举计划(095920201330)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据