从中医药干预核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)炎症小体入手,阐述中医药发挥抗炎的作用机理,认为NLRP3炎症小体参与的炎症反应贯穿动脉粥样硬化(atherosclerosis,AS)发展的全过程,其中清热药、活血药及补虚药在治疗AS中具有极大优势,为中医药治疗AS疾病提供新思路.
Research Progress of TCM Intervention of NLRP3 Inflammasome in the Treatment of Atherosclerosis
Based on the intervention of traditional Chinese medicine on nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,the paper discussed the anti-inflammatory mechanism of traditional Chinese medicine.It is believed that inflammatory response involved in NLRP3 runs through the entire process of the development of atherosclerosis(AS).Among them,heat-clearing drugs,blood-activating drugs and deficiency-tonifying drugs have great advantages in the treatment of AS,providing new ideas for traditional Chinese medicine treatment of AS.
atherosclerosisnucleotide-binding oligomerized structural domain-like receptor protein 3inflammasomeChinese medicine
NETL
NSTL
万方数据
维普
