Clinical Study of Danhuang Huazhuo Tongyu Pills in the Treatment of Gouty Nephropathy
Objective:To observe the therapeutic efficacy and safety of Danhuang Huazhuo Tongyu pills(Danhuang Turbidity-resolving Stasis-removing pills)in the treatment of gouty nephropathy.Methods:All 100 cases of gouty nephropathy were selected and randomly divided into observation group and control group,50 cases in each group.The control group was treated with symptomatic treatments such as regulating blood lipids,pain relief,and oral allopurinol and candesartan,while the observation group was treated with Danhuang Huazhuo Tongyu pills on the basis of this treatment the control group accepted.Both groups were evaluated after 12 weeks of treatment,and blood uric acid,24 h urine protein quantification,urine microalbumin/creatinine,β2 micro-globulin and the occurrence of adverse reactions were measured before and after treatment.Results:The total effective rate of the observation group[94.0%(47/50)]was higher than that of the control group[78.0%(39/50)](P＜0.05).Serum uric acid,24-hour urine protein,urinary microalbumin/creatinine,and β2 microglobulin in both groups were all reduced compared with before treatment(P＜0.05);among them,serum uric acid and β2 microg-lobulin in the observation group were decreased more than those in the control group(P＜0.05).There was no significant changes in blood routine,liver and kidney function before and after treatment in the two groups,and no obvious adverse reactions occurred.Conclusion:On the basis of conventional application of Western medicine,the treatment of gouty nephropathy with the pill can obviously reduce uric acid and proteinuria,improve clinical symptoms,which is safe and reliable.
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NSTL
万方数据
维普
