The Influence of Wentong Acupuncture Combined with Tonifying Liver and Kidney Formula on Bone Metabolism Indexes and Inflammatory Factor Levels in Patients with Acute Exacerbations of Knee Osteoarthritis
Objective:To investigate the influence of Wentong acupuncture and tonifying liver and kidney formula on bone metabolism indexes and inflammatory factor levels in patients with acute exacerbation of knee osteoarthritis(KOA).Methods:One hundred patients with acute exacerbation of KOA were divided into 50 cases each in Wentong acupuncture group and the combination group according to the complete randomization method.Patients in the Wentong acupuncture group were given Wentong acupuncture treatment,and patients in the combination group accepted Wentong acupuncture and tonifying liver and kidney formula.To observe the TCM syndrome scores,visual analogue scale(VAS)scores,Lysholm index,knee range of motion(ROM),bone metabolism indexes including COMP,OPG,OC and RANKL,inflammatory factors such as matrix metalloproteinase 3(MMP3),tumor necrosis factor α(TNF-α),interleukin-1β(IL-1β),cyclooxygenase 2(COX-2),and clinical effects of the patients in both groups.Results:After treatment,the TCM syndrome score,VAS scores and the levels of COMP,RANKL,and the levels of MMP-3,TNF-α,IL-1β,COX-2 of the combined group were lower than these before the treatment and the Wentong acupuncture group after the treatment(P<0.05),and Lysholm,knee ROM,and the levels of OPG,OC were higher than these before the treatment and the Wentong acupuncture group after the treatment(P<0.05).The total effective rate of the combination group was 98.00%(49/50),higher than 84.00%(42/50)of the Wentong acupuncture group(P<0.05).Conclusion:The combination of Wentong acupuncture with tonifying liver and kidney formula can effectively improve the levels of bone metabolism indexes,reduce VAS scores and inflammatory factor,and enhance Lysholm and knee ROM in patients with acute exacerbation of KOA,and the effect is better than that of Wentong acupuncture method alone.
knee osteoarthritis,acute exacerbationbone metabolism indexesinflammatory factorsWentong acupuncturetonifying liver and kidney formula
万方数据
维普
