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吴茱萸汤治疗呕吐的方证关系研究

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目的:探索吴茱萸汤治疗呕吐的方证关系.方法:从中国知网数据库检索吴茱萸汤治疗呕吐的医案100个,将医案中的相关症状(体征)、治法、药物等信息进行规范化处理,建立数据库.应用关联规则数据挖掘方法分析医案中症状(体征)、药物、治法的频数、支持度、置信度、提升度及其关联关系.结果:收集到的100个医案共涉及166个症状(体征),1432频次,其中以呕吐为首出现频次较高的症状(体征)19个;共涉及75味中药,671频次,其中以吴茱萸为首出现频次较高的中药13味;共涉及治法37种,385频次,其中以"降逆"为首出现频次较高的治法7种.共涉及提升度≥1.3的症状(体征)关联规则16个,提升度≥1.2的中药关联规则6个,均具有明显的核心化倾向.结论:运用关联规则的数据挖掘方法可以较好发现吴茱萸汤及其加减方治疗呕吐的症状(体征)、药物组方及治法的关联规律,可为临床遣方用药提供依据.
Study on the Formulae-syndrome Relationship in the Treatment of Vomiting by Wuzhuyu Tang
Objective:To explore the formula-syndrome relationship in the treatment of vomiting by Wuzhuyu Tang.Methods:All 100 cases of clinical application of the formula in the treatment of vomiting were retrieved from China National Knowledge Infrastructure(CNKI),and the information of symptoms(body signs),therapeutic methods and drugs in the cases were standardized to establish the database.The data mining method was applied to analyze the frequency,support,confidence,and enhancement of symptoms(body signs),drugs,and remedies in the medical cases,and to analyze the association relationship.Results:The collected 100 medical cases involved 166 symptoms(signs)with the frequencies of 1432 times,among which 19 symptoms(signs)with high frequency appeared with vomiting as the first one;75 medicines with the frequencies of 671 times,among which 13 medicines with high frequency appeared with Wuzhuyu(Euodiae fructus)as the first one;a total of 37 therapeutic methods were involved with a frequency of 385,among which seven therapeutic methods appeared more frequently with"lowering the adverse flow of Qi"as the first one.A total of 16 symptom(sign)association rules with elevation≥1.3 and six drug association rules with elevation≥1.2 were involved,all of which had an obvious tendency to be coregulated.Conclusion:The data mining method of association rules can be used to better discover the association rules between symptoms,drug formulae and therapeutic methods of vomiting,and Wuzhuyu Tang and its modified formulas,which can provide a basis for clinical application of the prescription and the drugs.

vomitingassociation ruleWuzhuyu Tangformulae-syndrome relationship

杨坤、甘丽华、郭超峰

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广西中医药大学,广西 南宁 530001

广西中医药大学基础医学院,广西 南宁 530023

呕吐 关联规则 吴茱萸汤 方证关系

国家自然科学基金国家自然科学基金广西一流学科建设开放课题广西中医药大学研究生创新计划项目

82060915815608202019XK004YCXJ2021043

2024

西部中医药
甘肃中医药研究院

西部中医药

CSTPCD
影响因子:0.98
ISSN:1004-6852
年,卷(期):2024.37(5)
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