Correlation between Syndrome Differentiation and Typing,Plasma cTnⅠ Level and Thyroid Function in Heart Failure Patients
Objective:To investigate the correlation between syndrome differentiation and typing,plasma cTnⅠ level and thyroid function indexes in heart failure patients.Methods:Ninety-six patients with heart failure were selected and divided into four groups according to TCM patterns,and 24 patients with normal cardiac function in the same period were selected as the control group,to compare the levels of cTn Ⅰ and thyroid function indexes in each group,and Spearman correlation analysis was used to explore the relationship between thyroid function,cTn Ⅰ level and syndrome differentiation and typing in heart failure patients.Results:According to the decreasing order of serum total thyroxine(T4)and serum total triiodothyronine(T3),the groups ranked in the order:the control group>heart and lung Qi deficiency syndrome group>Qi and Yin deficiency syndrome group>Qi deficiency and blood stasis syndrome group>Yang deficiency and water flooding syndrome group(P<0.05),they ranked in the order of increasing cTnⅠ level:the control group<heart and lung Qi deficiency syndrome group<Qi and Yin deficiency syndrome group<Qi deficiency and blood stasis syndrome group<Yang deficiency and water flooding syndrome group(P<0.05).Through Spearman's correlation analysis,cardiopulmonary Qi deficiency syndrome,Qi and Yin deficiency syndrome,Qi deficiency and blood stasis syndrome,and Yang deficiency and water flooding syndrome were positively correlated with cTnⅠ(r=0.814,0.816,0.807,0.820,P<0.01),negatively correlated with T3(r=-0.367,-0.367,-0.372,-0.308,P<0.05),and significantly negatively correlated with T4(r=-0.332,-0.364,-0.345,-0.336,P<0.05);cTnⅠ was significantly negatively correlated with T3 and T4 in 96 patients with heart failure(P<0.05).Conclusion:With the progression of heart failure patients'conditions,i.e.cardiopulmonary Qi deficiency syndrome → Qi and Yin deficiency syndrome → Qi deficiency and blood stasis syndrome → Yang deficiency and water flooding syndrome,the levels of T4 and T3 were gradually decreased,and the level of cTnⅠ was gradually increased.The expressions of T3,T4,and cTnⅠ are of reference value for TCM diagnosis and typing of heart failure patients.
heart failuresyndrome differentiation and typingtroponin Ⅰthyroid functioncorrelation
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