The Medication Rules of Liver-kidney Depletion Pattern Brucellosis Based on TCMISS
Objective:To unearth the effective drug combination and new prescription by analyzing the medication laws of TCM therapy for liver-kidney depletion pattern brucellosis.Methods:The literature and medical cases of liver-kidney depletion pattern brucellosis were collected by searching the relevant database and checking the data,to screen the prescriptions of treating the disease.The database of prescription and drugs was established based on TCMISS V2.5,the data of the prescribed herbs,including medication frequency statistics,the rule of the prescriptions,was analyzed through association rule analysis method,entropy hierarchical clustering.Results:There were 54 symptoms of liver and kidney deficiency,and the frequency of symptoms was 224 times in total,of which 18 symptoms occurred more than five times,147 times in total,accounting for 65.6%of the total.All 17 prescriptions and 38 herbs were selected,the most frequently used herbs were Niuxi(achyranthis bidentatae radix),Gouqizi(lycii fructus),Danggui(angelicae sinensis radix),Xuduan(dipsaci radix)and Sangjisheng(taxilli herba),14 core drug combinations were obtained,the medication rule were mainly the compatibility between Niuxi,Dangshen(Codonopsis radix),Xuduan,Danggui,Sangjisheng,Gouqizi and Huangjing(polygonati rhizoma).four core combinations and two new prescriptions were gained.Conclusion:Liver-kidney depletion pattern brucellosis principally adopts the drugs of tonifying liver and kidney,strengthening the bones and muscles,relieving rheumatism,nourishing Qi and blood,the new prescription could reflect the thinking of eliminating the pathogen and enhancing healthy Qi,treating the symptoms and the root causes,strengthening the liver and kidney,eliminating rheumatism to enrich Qi and blood,heal the arthralgia.
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