Objective:To optimize the best alcohol extraction process of Baizhu(Atractylodis macroce-phalae rhizoma)and Chenpi(Citri reticulatae pericarpium)in Shenzhu spleen-adjusting granules.Methods:The contents of alcohol soluble extract,atractylolide Ⅰ and atractylolide Ⅲ in Shenzhu spleen-adjusting granules were used as the indexes of alcohol extraction process,and the influences of different factors and their levels on extraction process were investigated using multi-index comprehensive scoring method.Results:The best alcohol extraction process of Baizhu and Chenpi from the granules was A1B3C2D3,that is,ethanol concentrations 65%,adding ten times amount of ethanol,extracting for 1.5 h each time,three times.Conclusion:The optimized alcohol extraction process of Baizhu and Chenpi from Shenzhu spleen-adjusting granules is rational and feasible with high extraction efficiency of active ingredients.
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