多指标综合评分法优选参术调脾颗粒方中白术和陈皮的醇提取工艺
Optimization of Alcohol Extraction Process of Baizhu and Chenpi in Shenzhu Spleen-adjusting Granules by Multi-index Comprehensive Scoring Method
刘猛 1高家荣 2魏良兵2
作者信息
- 1. 皖西卫生职业学院附属医院,安徽 六安 237008
- 2. 安徽中医药大学第一附属医院,安徽 合肥 230031
- 折叠
摘要
目的:优选参术调脾颗粒方中白术和陈皮的最佳醇提取工艺.方法:以参术调脾颗粒中醇溶性浸出物、白术内酯Ⅰ和白术内酯Ⅲ的含量为醇提取工艺的考察指标,通过多指标综合评分法考察不同因素和水平对提取工艺的影响.结果:参术调脾颗粒方中白术和陈皮最佳醇提取工艺为A1B3C2D3,即乙醇浓度65%,加10倍量乙醇,每次提取1.5 h,提取3次.结论:优选的参术调脾颗粒方中白术和陈皮醇提取工艺合理可行,有效成分提取效率高.
Abstract
Objective:To optimize the best alcohol extraction process of Baizhu(Atractylodis macroce-phalae rhizoma)and Chenpi(Citri reticulatae pericarpium)in Shenzhu spleen-adjusting granules.Methods:The contents of alcohol soluble extract,atractylolide Ⅰ and atractylolide Ⅲ in Shenzhu spleen-adjusting granules were used as the indexes of alcohol extraction process,and the influences of different factors and their levels on extraction process were investigated using multi-index comprehensive scoring method.Results:The best alcohol extraction process of Baizhu and Chenpi from the granules was A1B3C2D3,that is,ethanol concentrations 65%,adding ten times amount of ethanol,extracting for 1.5 h each time,three times.Conclusion:The optimized alcohol extraction process of Baizhu and Chenpi from Shenzhu spleen-adjusting granules is rational and feasible with high extraction efficiency of active ingredients.
关键词
参术调脾颗粒/提取工艺/白术内酯Ⅰ/白术内酯Ⅲ/多指标综合评分法Key words
Shenzhu spleen-adjusting granules/extraction process/atractylenolide Ⅰ/atractylenolide Ⅲ/multi-index comprehensive scoring method引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据