建立椎间盘退变动物模型的研究进展
Research Progress in Establishing Animal Models of Intervertebral Disc Degeneration
檀盛 1邓强 2李建花 1张彦军 2王鹏 2郭铁峰 2罗林钊 2马平怡 1杜磊 1姚兴璋1
作者信息
- 1. 甘肃省中医院,甘肃 兰州 730050
- 2. 甘肃中医药大学,甘肃 兰州 730030
- 折叠
摘要
通过分析文献,发现目前常用的腰椎间盘退变(Intervertebral disc degeneration,IDD)动物模型的建立方法包括自体髓核移植法、等离子消融术、基因敲除法及机械损伤法.这些方法能够模拟人类IDD的病理生理过程,为研究疾病机制和新的治疗方法提供了有力支持.但目前的动物模型仍存在许多局限性,如模型建立难度大、费时费力、缺乏长期随访等.未来应改进现有模型,提高其仿真度和可重复性,寻找更准确的疾病模拟方法.同时,还需要开展更多关于IDD发病机制和治疗的基础研究,为临床治疗提供更有效的指导.
Abstract
At present,the commonly-used methods of establishing animal models of intervertebral disc degeneration cover autologous nucleus pulposus transplantation,plasma ablation,gene knockout,and mechanical injury through literature analysis.These methods could simulate the pathological and physiological processes of human intervertebral disc degeneration,which could produce the powerful support for the study on the mechanism of disease and the exploration of new therapeutic methods.However,there are still many limitations in current animal models,such as the difficulty of model establishment,time-consuming and labor-intensive,and the lack of long-term follow-up.The existing models should be improved in the future to raise their simulation and repro-ducibility,and find out more accurate methods to simulate diseases.Meanwhile,more basic researches on the pathogenesis and treatment of lumbar disc degeneration are needed to provide more effective guidance for clinical treatment.
关键词
椎间盘退变/动物模型/造模方法Key words
intervertebral disc degeneration/animal models/modelling method引用本文复制引用
基金项目
国家自然科学基金地区科学基金项目(82060879)
甘肃省自然科学基金(22JR5RA624)
甘肃省自然科学基金(2020-0406-JCC-0436)
甘肃省重点课题研发项目(GZKZ-2022-1)
出版年
2024
国家科技期刊平台
NSTL
万方数据