Objective:To discuss the mechanism of treating asthma in children with Guominjian.Methods:The active ingredients and the targets of Guominjian were searched from traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),the active ingredients of herbs-effective targets of the disease were sorted out to obtain protein-protein interaction(PPI)network,perform topology analysis and further conduct GO and KEGG pathway enrichment analysis.The processed active ingredients were used as small molecule ligands and protein targets as receptors for molecular docking,and the visual analysis of the molecular docking results was performed.Results:All 54 effective active ingredients of Guominjian were obtained,involving 137 potential targets and 157 signaling pathway.Conclusion:The active ingredients including quercetin,kaem-pferol,wogonin contained in Guominjian could act on PI3K/Akt,AGE/RAGE,tumor necrosis factor,IL-17 and others possibly via the core targets such as neurotrophic tyrosine kinase type 1 receptor,amyloid precursor protein and epidermal growth factor receptor,forming the therapeutic characteristics of multi-ingredient,multi-target and multi-pathway,thus treating asthma.
asthma in childrenGuominjiannetwork pharmacologymolecular docking
NETL
NSTL
万方数据
