Clinical Effects of Transcutaneous Electrical Nerve Stimulation and Collateral-dredging Arthralgia-removing Ointment for External Application in the Treatment of Knee Osteoarthritis and Its Influence on Synovial Immune Cells
Objective:To explore curative effects of transcutaneous electrical nerve stimulation(TENS)and collateral-dredging arthralgia-removing ointment for external application in the treatment of knee osteoarthritis and its influence on synovial immune cells and knee function.Methods:Sixty KOA patients were divided into the control group A,the control group B and the observation group with 20 cases in each group according to random number table method,the control group A was treated by TENS,the control group B by external use of collateral-dredging arthralgia-removing ointment+diclofenac sodium enteric-coated tablets,and the observation group by external use of collateral-dredging arthralgia-removing ointment+TENS,all the groups were treated for six weeks.To compare the expressions of IL-1,IL-6,TNF-α,IFN-γ,NO,SOD and MDA before and after the treatment in the three groups,VAS and LKSS were applied to assess the recovery conditions of knee joint.Results:After the treatment,VAS scores of the observation group were lower than these of the control group A and the control group B(P<0.05),LKSS scores higher than these of the control group A and the control group B(P<0.05);after the treatment,the levels of IL-1,IL-6,TNF-α,IFN-γ were lowered in the observation group,the difference had statistical meaning when compared with the control group A and the control group B(P<0.05);after the treatment,the expressions of NO and MDA were lowered,while the levels of SOD were increased in the observation group,the difference had statistical meaning when compared with the control group A and the control group B(P<0.05).Conclusion:TENS and collateral-dredging arthralgia-removing ointment are effective in the treatment of knee osteoarthritis eivdently,and could effectively relieve joint inflammation and oxidative stress response with noticeable effects of relieving pain.
NETL
NSTL
万方数据
