Theoretical mechanism of Longzhong bone-setting manipulation in the treatment of knee osteoarthritis(KOA)based on the concept of"tendon-bone balance"was explored from the development history of Longzhong bone-setting manipulation,Longzhong bone-setting manipulation-knee balance manipulation and the treatment of KOA by Longzhong bone-setting manipulation,Longzhong bone-setting balance manipulation focuses on the concept of"tendon-bone balance"on the foundation of traditional manipulation,integrating the thinking of combining motion and static,treating the tendon and bones together into the treatment of KOA,laying stress on the correction of musculoskeletal mechanical imbalance,achieving the goal of regulating the tendon and bones simultaneously,which could provide the new strategies for the treatment of early KOA by manipulation.