Objective:To systematically assess clinical effects and the safety of activating-blood resolving-stasis method joined with chemotherapy in the treatment of advanced gastric cancer.Methods:The literature was searched from CNKI,CBM,VIP,PubMed and EMbase,and the data was screened and extracted by two researchers independently according to the inclusion and exclusion standard,R software was used to perform Meta analysis.Results:The study has included ten studies and 735 patients.Meta analysis results showed that:activating-blood resolving-stasis method joined with chemotherapy in the treatment of advanced gastric cancer had the advantages in lifting short-term effective rate(OR=0.49,95%CI:0.28～0.85,P<0.01)and total effective rate(OR=0.43,95%CI:0.29～0.65,P<0.01),improving Karnofsky scores(SMD=1.42,95%CI:1.17～1.68,P<0.01),lowering the patients'incidences of adverse reactions,incluing the incidence of leukocyte decline(OR=0.27,95%CI:0.17～0.41,P<0.01),the incidence of nausea(OR=0.43,95%CI:0.25～0.75,P<0.01),the incidence of peripheral neurotoxicity(OR=0.53,95%CI:0.29～0.96,P<0.05),improving liver function(OR=0.44,95%CI:0.25～0.79,P<0.01),improving immune indicators,including NK(SMD=0.79,95%CI:0.45～1.12,P<0.01),CD3(SMD=1.68,95%CI:1.40～1.95,P<0.01),CD8(SMD=-0.40,95%CI:-0.64～-0.15,P<0.01),CD4(SMD=-0.45,95%CI:-0.73～-0.18,P<0.01),CD4/CD8(SMD=-0.52,95%CI:-0.85～-0.20,P<0.01),better than single chemo-therapy group,and the difference had statistical meaning(P<0.01).Conclusion:Activating-blood resolving-stasis method joined with chemotherapy in the treatment of advanced gastric cancer is superior to the conventional therapy in lifting clinical effects,improving immune condition and relieving adverse reaction.
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