The article expounds the relationship between intestinal flora and obesity,and the influence of TCM on intestinal flora in obese patients,it is pointed out that energy metabolism,chronic low-grade inflamma-tion,intestinal flora changes,abnormal brain-gut axis,and bile acid metabolism are the mechanism of causing gut microbiota disturbance and then obesity;herbal compounds,single herbs such as Huanglian(Coptidis rhizoma),Baizhu(Atractylodes macrocephala Koidz.),Lingzhi(Ganoderma)and Heye(Nelumbinis folium),combined with acupuncture could obtain definite clinical effects in the treatment of obesity,which could change the structure of intestinal flora in obese patients and maintain the hemostasis of gut microbia.