生津汤对干燥综合征患者AQP5及炎症因子的影响
Influence of Body Fluid-generating Decoction on AQP5 and Inflammatory Factors in Patients with Primary Sj?gren's Syndrome
张艺凡 1孙明辉1
作者信息
- 1. 辽宁中医药大学附属医院临床检验中心,辽宁 沈阳 110032
- 折叠
摘要
目的:观察生津汤对气阴两虚型原发性干燥综合征(primary Sjögren's Syndrome,pSS)患者血清水通道蛋白5(aquaporin 5,AQP5)、白细胞介素10(interleukin-10,IL-10)、IL-17等表达的影响.方法:将60例气阴两虚型pSS女性患者随机分为中药组和西药组各30例,中药组予生津汤,西药组予硫酸羟氯喹片,连续治疗12周后比较两组患者治疗前后中医症状评分、Schirmer Ⅰ试验值及血清免疫球蛋白G(im-munoglobulin G,IgG)、C反应蛋白(C-reaction protein,CRP)、AQP5、IL-17、IL-10表达水平.结果:治疗后两组患者中医症状积分及血清IgG、CRP、IL-17表达降低,Schirmer Ⅰ试验值、IL-10、AQP5表达升高(P＜0.05),除CRP外,中药组其余各指标改善程度均优于西药组(P＜0.05).结论:基于酸甘化阴理论的生津汤能改善pSS患者临床症状,其作用机制可能与生津汤能调节AQP5及IL-17、IL-10等炎症因子表达,抑制机体炎症反应有关.
Abstract
Objective:To observe the influence of Shengjin Tang(body fluid-generating decoction)on the expressions of AQP5,IL-10 and IL-17 in patients suffering Qi and Yin deficiency pattern primary Sjögren's syndrome(pSS).Methods:Sixty patients were randomly allocated to TCM group and Western medicine group with 30 cases in each group,TCM group took body fluid-generating decoction,and hydroxychloroquine sulfate tablets were dispensed to Western medicine group,both groups were treated for 12 weeks consecutively,to compare TCM symptom scales,Schirmer Ⅰ test values,the expressions of IgG,CRP,AQP5,IL-17 and IL-10 in the two groups before and after the treatment.Results:After the treatment,TCM symptom scores,and the expressions of IgG,CRP and IL-17 lowered in the two groups,Schirmer Ⅰ test values,the expressions of IL-10 and AQP5 increased(P<0.05),except for CRP,the improvements of other indexes of TCM group were better than these of Western medicine group(P<0.05).Conclusion:Body fluid-generating decoction,on the foundation of the theory of sour-sweet transformed into Yin,could improve pSS patients'clinical symptoms,and its mechanism might be related to that the decoction could regulate the expressions of AQP5,IL-17 and IL-10,and inhibit inflammatory response in human body.
关键词
原发性干燥综合征/水通道蛋白5/炎症因子/中医症状积分/酸甘化阴理论/生津汤Key words
primary Sjögren's syndrome/AQP5/inflammatory factors/TCM symptom scores/the theory of sour-sweet transformed into Yin/body fluid-generating decoction引用本文复制引用
基金项目
辽宁省自然科学基金(2014020049)
出版年
2024
国家科技期刊平台
NSTL
万方数据