Clinical Observation on Xuefu Zhuyu Tang Joined with Atorvastatin Calcium in the Treatment of Hyperlipidemia of Phlegm-dampness Internal Obstruction Pattern
Objective:To observe clinical effects of modified Xuefu Zhuyu Tang(Xuefu stasis-removing decoction)combined with atorvastatin calcium in the treatment of hyperlipidemia of phlegm-dampness internal obstruction pattern.Methods:All 74 patients were allocated to the control group and the observation group according to random number table method with 37 cases in each group,the control group was treated by atorvastatin calcium tablets,and the observation group took atorvastatin calcium tablets and modified Xuefu Zhuyu Tang,four weeks were one course of the treatment,and both groups were treated for two courses of the treatment.To compare the levels of blood lipid indicators including TC,TG,LDL-C and HDL-C,the indexes of vascular endothelial function such as ET-1,NO,6-keto-PGF-1α and TXB2,curative effects and the incidences of adverse reactions between the two groups.Results:After the treatment,LDL-C,TG and TC levels in the two groups were lower than before the treatment(P<0.05),HDL-C levels elevated than pre-treatment levels(P<0.05),and the differences had statistical meaning between the groups(P<0.05),after the treatment,the levels of 6-keto-PGF-1α and NO went up than pre-treatment level in the observation group(P<0.05),TXB2 and ET-1 levels reduced than pre-treatment level(P<0.05),and the differences had statistical meaning between the groups(P<0.05),total effective rate of the observation group was 94.6%(35/37),higher than 78.4%(29/37)of the control group of the control group(P<0.05);the incidences of adverse reaction of the observation group was 27.0%(10/37),lower than 8.1%(3/37)of the control group(P<0.05).Conclusion:Atorvastatin calcium and Xuefu Zhuyu Tang could improve blood lipid,vascular endothelial function,and clinical effects,and decrease the incidences of adverse reaction in treating phlegm-dampness internal obstruction type of hyperlipidemia.
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