Meta-Analysis of Bailing Capsules Combined with ACEI/ARB in the Treatment of Chronic Glomerulonephritis
Objective:To systematically assess the effectiveness and the safety of Bailing capsules combined with ACEI/ARB in the treatment of chronic glomerulonephritis(CGN).Methods:Clinical randomised controlled trials(RCTs)of Bailing capsules combined with ACEI/ARB in the treatment of CGN were searched from CNKI,Wanfang,VIP,SinoMed,Pubmed and Cochrane library,the period of search ranged from the establishment of the database to April 2021,the quality evluation and information extraction of the documents that met the inclusion and exclusion criteria were carried out,and Meta-analysis was performed using RevMan 5.3 software.Results:All 19 papers were included,involving 2157 patients.Meta-analysis results displayed that:compared with the control group,Bailing capsules combined with ACEI/ARB were better than the control gorup in improving clinical effective rate in CGN patients(OR=3.93,95%CI:2.98～5.19,P<0.000 01),reducing SCr(MD=-16.36,95%CI:-22.28～-10.44,P<0.000 01),lowering urea nitrogen(MD=-1.54,95%CI:-1.63～-1.46],P<0.000 01),and decreasing the quantification of 24 h-proteinuria(MD=-0.40,95%CI:-0.43～-0.38,P<0.000 01).Conclusion:Bailing capsules combined with ACEI/ARB could enhance clinical effects in the treatment of CGN,it is better than single use of ACEI or ARB in decreasing SCr,urea nitrogen and the quantification of 24 h-proteinuria.
NETL
NSTL
万方数据
