Study on the Medication Rule of Habitual Abortion in Ancient Gynecological Medical Books Based on Data Mining
Objective:To provide theoretical evidence for clinical therapy of habitual abortion(HA)by sorting up the documentary records about habitual abortion in ancient gynecological medical books and exploring the characteristics of the medication and the laws of compatibility of the treatment of habitual abortion.Methods:Representative gynecological monographs of the past dynasties were chosen to search the prescriptions of treating HA,Excel was applied to conduct the statistics on the frequency of medication,types of medication and the properties,flavors and meridian tropism of the medications,VOSviewer1.6.15 software was used to analyze the general conditions of the medications,Origin 2022 software was utilized to draw the thermal map of the nature,flavor and meridian tropism,SPSS Modeler 18.0 to analyze association rules between the drugs,SPSS 26.0 to perform cluster analysis,factor analysis and decision tree of high-frequency drugs.Results:A total of 77 ancient gynaecological monographs were screened,and 79 prescriptions were included,involving 97 Chinese medicines were involved,and the total frequency of medication was 719 times.The drugs used in the top five frequencies were Danggui(Angelicae sinensis radix),Baizhu(Atractylodes macrocephala Koidz.),Chuanxiong(Chuanxiong rhizoma),Gancao(Glycyrrhizae radix et rhizoma)and ginseng,the commonly used drugs were these of tonification,clearing heat,activating blood and resolving stagnation,belonging to the warm nature,sweet and bitter flavors,mainly entering the meridians of spleen,liver and kidney.Association rule analysis showed that the drug combinations with the highest confidence level were Danggui-Baishao,Danggui-Chuanxiong.Cluster analysis has yielded five core clustering formulae,factor analysis has extracted seven common factors,the decision tree model with Danggui as the dependent variable showed that Baishao was the best identified.Conclusion:In clinical treatment of HA,ancient physicians paid attention to the functional restoration of spleen,liver and kidney,benefitting the deficiency,including invigorating Qi,nourishing blood,invigorating spleen and benefitting kidney;reducing the excess,covering resolving the stasis and clearing heat,they adopted nourishing and replenishing the deficiency as therapeutic principles;flexible application of the methods of activating blood and resolving stagnation,clearing heat could obtain the effects of strengthening Chong-Ren and preserving the natal element.
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