肠道微生物诱导胆囊结石形成机制的研究进展
Research Progress of the Mechanism of Gallbladder Calculus Formation Induced by Gut Microorganisms
潘浩宇 1刘志春 2张春花 2王定新3
作者信息
- 1. 甘肃中医药大学第一临床医学院,甘肃 兰州 730000
- 2. 天水市第一人民医院,甘肃 天水 741000
- 3. 天水市卫生健康委员会,甘肃 天水 741000
- 折叠
摘要
研究证实肠道微生物通过多种途径参与胆囊结石的发生、发展,湿热证是胆囊结石的中医病机,而肠道微生物与湿热证相互作用,相互影响.文章从肠道微生物及其代谢产物通过调控胆汁酸代谢及中医湿热内蕴引起肠道微生物失衡而诱发胆囊结石等方面阐述肠道微生物引起胆囊结石的发生机制,并指出调整肠道微生物及其代谢产物可能是预防和治疗胆囊结石的新的治疗方向.
Abstract
More and more research has confirmed that gut microorganisms are involved in the occurrence and development of gallbladder stones,interacting with the damp-heat pattern,as damp-heat pattern is the pathogenesis of gallbladder stones in TCM.The mechanism of gallbladder stone formation induced by intestinal microorganisms was elaborated from the aspects that intestinal microorganisms and their metabolites regulate the metabolism of bile acids,and the imbalance of intestinal microorganisms caused by the internal accumulation of damp-heat,thereby inducing gallbladder stones,meanwhile,the regulation of intestinal microorganisms and their metabolites might be the new therapeutic direction for the prevention and treatment of gallbladder calculus.
关键词
胆囊结石/肠道微生物/胆汁酸/湿热证/机制Key words
gallbladder calculus/gut microorganisms/bile acid/damp-heat pattern/the mechanism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据