首页|A Two-Way FSI Model for Pathologic Respiratory Processes with Precisely Structured and Flexible Upper Airway

A Two-Way FSI Model for Pathologic Respiratory Processes with Precisely Structured and Flexible Upper Airway

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A Two-Way FSI Model for Pathologic Respiratory Processes with Precisely Structured and Flexible Upper Airway
The human body displays various symptoms of altitude sickness due to hypoxia in environments with low pressure and oxygen levels.While existing studies are primarily focused on the adverse effects of hypoxia and oxygen supplementation strategies at high altitudes,there is a notable gap in understanding the fundamental mechanisms driving altitude hypoxia.In this context,we propose a sophisticated two-way fluid-structure interaction model that simulates respiratory processes with precisely structured and deformable upper airways.This model reveals that,under identical pressure differentials at the airway's inlet and outlet,the inspiratory air volume remains largely consistent and is minimally affected by specific pressure changes.However,an increase in the pressure differential enhances gas inhalation efficiency.Furthermore,airway morphology emerges as a pivotal factor influencing oxygen intake.Distorted airway shapes create areas of high flow velocity,where low wall pressure hampers effective airway opening,thus diminishing gas inhalation.These results may shed light on the effects of low-pressure conditions and upper airway structure on respiratory dynamics at high altitudes and inform the development of effective oxygen supply strategies.

Mechanical modelMechanics of soft tissuesRespiratory processFlexible

Yuan Qin、Honghao Zhang、Zhiwei Qiu、Lei Liu、Hui Yang、Jiutao Hang、Dong Wei、Guangkui Xu

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Department of Engineering Mechanics,SVL,School of Aerospace Engineering,Xi'an Jiaotong University,Xi'an 710049,China

School of Mechanical Engineering,Northwestern Polytechnical University,Xi'an 710000,China

State Key Laboratory of Aerodynamics,China Aerodynamics Research and Development Center,Mianyang 621000,Sichuan,China

School of Life Sciences,Northwestern Polytechnical University,Xi'an 710000,China

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Mechanical model Mechanics of soft tissues Respiratory process Flexible

2024

10.1007/s10338-024-00510-7

固体力学学报(英文版)
中国力学学会

固体力学学报(英文版)

EI
影响因子：0.214
ISSN：0894-9166
年,卷(期)：2024.37(6)