首页|蛇黄凝胶与蛇黄散体外释放与透皮特性比较研究

蛇黄凝胶与蛇黄散体外释放与透皮特性比较研究

扫码查看
原文链接
  • 万方数据
  • 维普
目的 比较蛇黄散与其改良剂型蛇黄凝胶的体外释放度与透皮特性。方法 分别采用微孔滤膜与离体小鼠鼠皮及改进的Franz扩散池进行体外释放与透皮试验，以HPLC法定量测定蛇黄凝胶与蛇黄散中君药—蛇鳞草中triphyllin A与大黄中大黄酸的量为指标，测定2种制剂的体外释放量(Qs)、释放率(Q)、透皮量(Ls)与透皮率(L)，并采用3种方程对蛇黄凝胶的体外释放与透皮结果进行模拟拟合。结果 蛇黄凝胶中 triphyllin A 24 h 的Qs=72。188 5 μg·cm-2，Q=30。458 3％，Ls=52。086 7 μg·cm-2，L=21。976 8％，大黄酸 24 h 的 Qs=15。220 0 μg·cm-2，Q=9。429 0％，Ls=13。545 6 μg·cm-2，L=8。3917％，蛇黄散中 triphyllin A24h的Qs=45。2395 μg·cm-2，Q=17。124 9％，Ls=27。0434 μg·cm-2，L=10。237 0％，大黄酸24h的Qs=6。376 3 μg·cm-2，Q=l。992 1％，Ls=5。875 1 μg·cm-2，L=1。835 5％。结论 改良后的蛇黄凝胶体外Qs、Q、Ls与L均优于蛇黄散，释放与透皮特征明显优于传统剂型蛇黄散，且蛇黄凝胶不易过敏，贴敷方便，便于临床使用;蛇黄凝胶释放与透皮模型均符合Higuchi方程，说明蛇黄凝胶体外释放和透皮均属于骨架型缓释制剂。
Comparative Study on Release and Transdermal Behavior in vitro between Shehuang Gels and Shehuang Powder
OBJECTIVE To compare the release and transdermal behavior in vitro between Shehuang gels and Shehuang powder.METHODS Microporous fliter membrane and isolated rat skin and advanced Franz diffusion cell were chosen in the release and transdermal behavior in vitro between Shehuang gels and Shehuang powder.The content of triphyllin A in Pronephrium triphyllum and rhein in rheum of Shehuang gels and Shehuang powder were quantitatively determined by HPLC method to determine the penetration quantity and penetration rate of the two forms.The in vitro release and transdermal results of Shehuang gels were simulation fitting by 3 equations.RESULTS The triphyllin A of Shehuang gels in 24 h were Qs=72.188 5 μg·cm-2,Q=30.458 3％,Ls=52.086 7 μg·cm-2,L=21.976 8％.The rhein of Shehuang gels in 24 h were Qs=15.220 0 μg·cm-2,Q=9.429 0％,Ls=13.545 6 μg·cm-2,L=8.391 7％.The triphyllin A of Shehuang powder in 24 h were Qs=45.239 5 μg·cm-2,Q=17.124 9％,Ls=27.043 4 μg·cm-2,L=10.237 0％.The rhein of Shehuang powder in 24 h were Qs=6.376 3 μg·cm-2,Q=1.992 1％,Ls=5.875 1 μg·cm-2,L=1.835 5％.CONCLUSION The Qs、Q、Ls and L of Shehuang gels are obviously better than the Shehuang powder.Meanwhile the Shehuang gels is less sensitized and more convenient to use in clinical.The release and transdermal model of Shehuang gels are coincides with Higuchi equation,the release and transdermal behavior of Shehuang gels are all belong to skeleton sustained-release preparations.

Shehuang powderShehuang gelstriphyllin Arheinexperiment on releasetransdermal behavior in vitro

汪亚飞、冯洁颖、吴惠妃、梅全喜

展开 >

中山市中医院,广东中山 528401

宝安纯中医治疗医院,广东深圳 518101

蛇黄凝胶 蛇黄散 triphyllin A 大黄酸 释放试验 透皮试验

中山市医学科研项目(2022)

2022J006

2024

10.12048/j.issn.1674-229X.2024.02.004

今日药学
广东省药学会 中国药学会

今日药学

影响因子：0.413
ISSN：1674-229X
年,卷(期)：2024.34(2)
  • 22