Investigation and Evaluation of the Off-label Use of Lenvatinib
OBJECTIVE To investigate the off-label use of lenvatinib in our hospital and provide reference for its clinical use.METHODS A retrospective study was conducted on the prescriptions of lenvatinib used in outpatient and emergency department of the hospital in 2022,and the diagnostic information of prescription-related patients was recorded.The existence of off-label drug use in the collected prescriptions of lenvatinib was judged by referring to the latest version of the drug instructions of lenvatinib.Consulting relevant literature and database,classifying and making statistics on the prescriptions judged to be off-label drug use,and collecting evidence-based medical evidence.RESULTS A total of 2 361 outpatient prescriptions of lenvatinib were collected,of which 81 were off-label drug use,accounting for 3.43％.The department with the highest incidence were surgery and oncology.Among 81 cases of off-label drug use,31 cases(38.27％)were supported by strong evidence-based medical evidence.There were 40 cases with weak evidence-based medical evidence,accounting for 49.38％;There were 10 prescriptions without evidence,accounting for 12.34％.CONCLUSION There are off-label drug use without evidence of lenvatinib,so the management of off-label drug use should be strengthened to improve the rationality and safety of drug use.
lenvatiniboff-label drug useevidence-based medicinedrug use evaluation
万方数据
维普
