Analysis of the Prescription and Medication Rules of Formulations Containing Magnolia Officinalis in the Chinese Pharmacopoeia Based on Data Mining
OBJECTIVE To explore the prescription and medication rules of formulations containing Magnolia officinalis in the Chinese Pharmacopoeia of 2020 edition,andto provide reference for the modem clinical scientific use of Magnolia offcinalis,planting Magnolia officinalis and related new prescription research and development.METHODS All formulated preparations containing Magnolia officinalis in the Chinese Pharmacopoeia of 2020 edition had been collected and a database had been established.Using software such as Excel(2019 version),IBM SPSS Modeler 18.0,and Cytoscape 3.9.1,statistical analysis was conducted on the dosage form,frequency of medication,nature,taste,meridian tropism,and indications of the prepared formula.Compatibility analysis was also conducted on high-frequency syndrome combinations.RESULTS 57 prescription formulations containing Magnolia officinalis were screened,involving 222 medicinal herbs,with a cumulative frequency of 926 occurrences.The dosage form was mainly pills.The most frequently used traditional Chinese medicine was Magnolia officinalis,Citrus reticulata Blanco,Radix Aucklandiae,and Glycyrrhiza uralensis Fisch.The main types of drugs were regulating qi,resolving dampness,tonifying deficiency,relieving external symptoms,and clearing heat.The main properties and flavors were warm,cold,calm,spicy,bitter,and sweet.The drugs that regulate the spleen,stomach,and lung meridians were the majority.And there was a close compatibility relationship between Magnolia officinalis and Citrus reticulata Blanco,Glycyrrhiza uralensis Fisch,and Radix Aucklandiae.Using association rule analysis for high-frequency syndromes,it was found that Magnolia officinalis could exert different effects in different syndromes and combinations.CONCLUSION The data mining method showcases the medication patterns of Magnolia officinalis prescription formulations,providing reference for the rational clinical application of Magnolia officinalis and the subsequent development of new prescription formulations.
data miningMagnolia officinalisprescription preparationformulation rules
万方数据
维普
