Changes and Clinical Significance of Serum OPG、RANK and RANKL Levels in Patients With Non-traumatic Osteonecrosis of the Femoral Head
OBJECTIVE To explore the changes and significance of serum osteoprotegerin(OPG),receptor activator of nuclear factor-KB(RANK)and receptor activator for nuclear factor-KB ligand(RANKL)levels in patients with non-traumatic osteonecrosis of the femoral head(NONFH).METHODS 85 patients with NONFH who received treatment in a hospital from January to June 2019 were selected as the observation group(NONFH group)and 55 healthy adults who received physical examination at the same period were selected as the control group.The albow venous blood was collected at fasting in the morning,and the serum was separated.The levels of OPG,RANK and RANKL in the serum were detected by double antibody sandwich enzyme-linked immunosorbent assay(ELISA).At the same time,the effects of different gender,causes,onset side,ARCO stage and age on serum OPG,RANK and RANKL levels in NONFH patients were analyzed.RESULTS Compared with the control group,the OPG level in the serum of patients in the NONFH group was significantly reduced(P=0.000),the levels of RANK and RANKL were significantly increased(P=0.000,P=0.001),and the OPG/RANKL ratio was significantly reduced(P=0.000).The OPG,RANK and RANKL levels in serum of patients with femoral head necrosis caused by different etiologies(hormonal,alcoholic,and idiopathic)were not statistically significant(P=0.170,P=0.730,P=0.084).The serum OPG,RANK and RANKL levels of NONFH patients with different incidence sides,different ARCO stages,different genders and different ages were not statistically significant(all P＞0.05).CONCLUSION The serum level of OPG in patients with NONFH is significantly lower than that in healthy people,while the serum levels of RANK and RANKL are significantly higher than that in healthy people,suggesting that OPG/RANK/RANKL system is involved in the pathogenesis and development of NONFH.This shows that non-traumatic ONFH bone metabolism abnormalities,hormones,alcohol and primary factors cause bone loss,which is closely related to OPG,RANK levels and the ratio of OPG/RANKL,while the levels of OPG,RANK and RANKL are not related to causes,sides,ARCO stages,genders,and ages.
Non-traumatic osteonecrosis of the femoral headosteoprotegerinreceptor activator of nuclear factor-κBreceptor activator for nuclear factor-κB ligandclinical significance
万方数据
维普
