Effect of Sacubitril and Valsartan Sodium on Serum sFRP5,VS-2,and GRK2 Levels in Patients With Heart Failure After Acute Myocardial Infarction
OBJECTIVE To investigate the effects of sakubatrotril valsartan sodium on serum secretory frizzle-associated protein 5(sFRP5),vasostatin 2(VS-2)and G protein coupled receptor kinase 2(GRK2)levels in patients with heart failure after acute myocardial infarction(AMI).METHODS A total of 108 patients with heart failure after AMI admitted to Fengcheng People's Hospital in Jiangxi Province were divided into Group A and Group B using a random number table method,with 54 cases in each group.Group B received conventional treatment,while Group A received additional treatment with sacubitril and valsartan sodium.The serum sFRP5,VS-2,GRK2 levels,ventricular remodeling and heart function indicators,clinical symptoms,quality of life,and adverse reactions were compared between the two groups.RESULTS After treatment,left ventricular end-diastolic septal thickness(IVST),left ventricular end-diastolic diameter(LVEDd),left ventricular end-systolic posterior wall thickness(LVPWT),left ventricular end-systolic diameter(LVESd)and left ventricular mass index(LVMI)in group A were lower than those in group B,and cardiac output index(CI)was higher than those in group B(P＜0.05).After treatment,sFRP5 and VS-2 levels in group A were higher than those in group B,and GRK2 levels were lower than those in group B(P＜0.05).After treatment,the levels of sFRP5 and VS-2 in Group A were higher than those in Group B,while the levels of GRK2 were lower than those in Group B(P＜0.05).After treatment,the Lee's heart failure score and cardiac dysfunction quality of life questionnaire(MLHFQ)score in Group A were lower than those in Group B(P＜0.05).There was no statistically significant difference in the overall incidence of adverse reactions between Group A and Group B(P＞0.05).CONCLUSION Sacubitril valsartan sodium can improve heart function,myocardial remodeling,serum sFRP5 and VS-2 levels,reduce GRK2 expression,and improve clinical symptoms in patients with heart failure after AMI.
sacubitril valsartan sodiumheart failure after acute myocardial infarctionsecretory curl related protein 5vascular inhibitory factor-2G protein coupled receptor kinase 2
万方数据
维普
