Study on the Pharmacological Effects of Compound Danshen Dripping Pills in Regulating Non-alcoholic Fatty Liver in Mice
OBJECTIVE To study the pharmacodynamic effects of compound Danshen dropping pills on nonalcoholic fatty liver(NAFLD)in mice,and explore the feasibility of its treatment on nonalcoholic fatty liver.METHODS SPF male C57BL/6 mice were fed with a standard diet for one week and then randomly divided into the normal group and high-fat diet group.The normal group was fed with a regular diet,while the high-fat diet group was fed with a high-fat diet.After 8 weeks,the high-fat diet group was further divided into the model group,compound Danshen dripping pills group(CDDP),positive control atorvastatin group(Ator),and compound Danshen dripping pills+atorvastatin combination group(CDDP+Ator).Each group was given corresponding drug by intragastric administration for 5 weeks,while the normal group and the model group were given an equivalent volume of saline.After the administration,the mice underwent oral glucose tolerance test(OGTT),biochemical index detection,and liver histopathological observation.RESULTS Compared with the Normal group,mice in the Model group showed rapid weight gain,significantly increased blood glucose levels,OGTT-area under the curve(AUC),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-c),alanine aminotransferase(ALT),aspartate aminotransferase(AST)(P＜0.01),and significantly decreased high-density lipoprotein cholesterol(HDL-c)(P＜0.01),along with more hepatic fat deposition.Compared with the Model group,mice in the CDDP group showed slower weight gain,decreased blood glucose levels,OGTT-AUC,TG,TC,LDL-c,ALT,and AST(P＜0.01;P＜0.05),and less hepatic fat deposition.CONCLUSION Compound Danshen dripping pills have the potential to reduce body weight,blood glucose levels,blood lipids,improve liver function and abnormal glucose tolerance,and alleviate hepatic steatosis and deposition in NAFLD mice.Further researchs are ineeded to explore the underlying therapeutic mechanisms of compound Danshen dripping pills on NAFLD and its possibility as a treatment for NAFLD.
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