Effect of Huangjing on Lowering Lipid in Hyperlipidemia Model Rats
OBJECTIVE To investigate the effect of Huangjing on blood lipids and other indexes in hyperlipidemia rats.METHODS After 7 days of adaptive feeding,SD rats were randomly divided into blank group,model group,atorvastatin calcium group(9 mg·kg-1)and Huangjing group(1.35 g·kg1)by random number table method,with 10 rats in each group.In addition to the normal group,the other groups were continuously gavaged with emulsionfor 30 days with an intragastric volume of 10 mL·kg-1.From the 16th day,each administration group was given the corresponding concentration of liquid medicine,and the blank group and model group were given the same amount of normal saline,once a day for 14 days.The weight increase,pathological changes of liver tissue and liver coefficient of rats were observed.RESULTS Compared with blank control group,the body weight of rats in model group was significantly reduced(P＜0.01),and the body weight of rats in atorvastatin calcium group and Huangjing group were significantly increased(P＜0.05,P＜0.01).Compared with the normal control group,the liver coefficient of the model group was significantly increased(P＜0.01).Compared with model group,the liver coefficient of atorvastatin calcium group and Huangjing group was significantly decreased(P＜0.01).Compared with blank group,the contents of TG,CHO and LDL in serum of model group were significantly increased(P＜0.01).HDL content was decreased(P＞0.05).Compared with model group,the contents ofTG,CHO and LDL in atorvastatin calcium and Huangjing groups were significantly decreased(P＜0.05,P＜0.01),and the contents of HDL were increased(P＞0.05).Huang jing group significantly improved hepatic steatosis in rats.CONCLUSION Huangjing may have protective effect on liver tissue by reducing abnormal blood lipid level in hyperlipidemia rats.
NETL
NSTL
万方数据
