Using the Compatibility of Licorice and Kudzu to Explore the Functional Characteristics of Licorice's Unification of Drugs and Excipients
OBJECTIVE To explore the unification of drugs and excipients role of licorice in the compatibility of licorice and kudzu using the active ingredients of licorice and kudzu.METHODS Establish the HPLC method of puerarin to measure the changes in the solubility of puerarin under different concentrations of glycyrrhizic acid.Measure the changes in the transdermal rate of puerarin under different concentrations of glycyrrhizic acid through a Franz diffusion cell.RESULTS The HPLC method of puerarin complies with the regulations.Glycyrrhizic acid could improve the solubility and transdermal rate of puerarin.CONCLUSION In the compatibility of licorice and kudzu,the presence of glycyrrhizic acid can change the action characteristics of the cell membrane,thereby explaining the unification of drugs and excipients effect of licorice.
licoriceglycyrrhizic acidpuerarincompatibilityunification of drugs and excipients
NETL
NSTL
万方数据
