Clinical Practice of Secondary Thrombocytosis Induced by Imipenem/Cilastatin by Using Modified Naranjo's Assessment Scale:A Case Report
OBJECTIVE To evaluate the causality relationship between the adverse drug reactions(ADR)of thrombocytosis and imipenem/cilastatin by using modified Naranjo's assessment scale and provide references for clinical medication safety.METHODS Based on the medical history and medication history,the correlation between imipenem/cilastatin and thrombocytosis was analyzed using the association evaluation criteria developed by the National Center for Adverse Drug Reaction Testing and the modified Naranjo's assessment scale,and the results were evaluated.Then patient's medication was adjusted and individualized by pharmacists cooperated with physicians according to results.RESULTS The causal association between thrombocytosis and imipenem/cilastatin scored 7 points with modified Naranjo's assessment scale,indicating the probable causality of the ADR and drug,which was consistent with the evaluation result obtained using the association evaluation criteria developed by the National Center for Adverse Drug Reaction Testing.After discontinuing the medication,the platelet count of the patient gradually decreased,and the patient was discharged in a good condition.CONCLUSION Thrombocytosis induced by imipenem/cilastatin is easily ignored,which may lead to thrombosis or abnormal bleeding events.So different measures should be taken by medical personnel depending on the degree of platelet elevation and the patient's condition.
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