首页|免疫原性细胞死亡与乳腺癌治疗的研究进展

免疫原性细胞死亡与乳腺癌治疗的研究进展

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免疫原性细胞死亡(immunogenic cell death,ICD)是一种特殊形式的细胞死亡,其在乳腺癌的治疗中发挥着重要作用。研究表明,利用特定的化疗药物、放射疗法或靶向药物等治疗乳腺癌时,肿瘤细胞会释放或增加表达损伤相关分子模式(damage associated molecular patterns,DAMPs),激活ICD从而提高肿瘤细胞的免疫原性,募集和激活免疫细胞,进一步激发或增强抗肿瘤免疫反应。本文对利用诱导ICD治疗乳腺癌的相关临床前研究进行总结,为乳腺癌临床治疗方案选择提供参考和思路。
Research Progress on the Immunogenic Cell Death and the Treatment of Breast Cancer
Immunog enic cell death(ICD)is a special form of cell death,which plays an important role in the treatment of breast cancer.Research shows that when specific chemotherapy drugs,radiotherapy or targeted drugs are used to treat breast cancer,tumor cells will release or increase the expression of damage associated molecular patterns(DAMPs),activate ICD,thereby improving the immunogenicity of tumor cells,recruiting and activating immune cells,and further stimulate or enhance anti-tumor immune response.This article summarizes the relevant preclinical studies on the use of induced ICD in the treatment of breast cancer,and provides a reference for the design of breast cancer therapy in the future.

immunogenic cell deathdamage associated molecular patternsbreast cancerchemotherapyradiation therapy

郑好、何祥久、徐静雯

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广东药科大学药学院,广东广州 510006

免疫原性细胞死亡 损伤相关分子模式 乳腺癌 化疗 放疗

广东省医学科学技术研究项目广东省科技创新战略专项(大学生科技创新培育)项目

A2023211pdjh2023b0280

2024

今日药学
广东省药学会 中国药学会

今日药学

影响因子:0.413
ISSN:1674-229X
年,卷(期):2024.34(7)