OBJECTIVE To investigate the effect of ginkgo biloba extract on patients with idiopathic sudden deafness and its impact on serum levels of NOD-like receptor protein 3(NLRP3)and Caspase-1.METHODS Clinical data of 80 patients with idiopathic sudden deafness admitted from October 2021 to October 2023 were collected.Patients were divided into two groups based on treatment plans:a combination group of 42 patients and a control group of 38 patients.The control group received conventional treatment,while the combined group received the same treatment plus ginkgo biloba extract,with both groups treated for 10 consecutive days.The efficacy and adverse reactions of the two groups were compared.As well as the inflammatory indexes,anticoagulant protein indexes and serum NLRP3 and Caspase-1 mRNA levels before and after treatment.RESULTS The total effectiveness rate of the combination group was significantly higher than that of the control group(P＜0.05).After treatment,the levels of IL-6,TNF-α,CRP,and the mRNA expressions of serum NLRP3 and Caspase-1,were decreased in both groups.Activities of anticoagulant proteins PC,PS,and AT-Ⅲ increased compared to pre-treatment levels,with the combination group showing superior results(P＜0.05).Average hearing threshold at all frequenciesimproved post-treatment,with the combination group showing greater improvements(P＜0.05).There was no significant difference in adverse reactions between the groups(P＞0.05).CONCLUSION Ginkgo biloba extract significantly improves outcomes for patients with idiopathic sudden deafness,potentially by downregulating the expression of NLRP3 and Caspase-1,and can improve inflammatory factors and coagulation protein levels,promoting recovery of hearing function.
关键词
Nod样受体蛋白3/特发性突聋/半胱氨酸蛋白酶-1/银杏叶提取物
Key words
Nod-like receptor protein 3/idiopathic sudden deafness/cysteine proteinase-1/ginkgo biloba leaf extract
维普
万方数据