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住院患者血流感染病原菌耐药性及危险因素分析

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目的 对广州市某三甲医院的住院患者血流感染病原菌耐药性及危险因素进行分析探讨。方法 收集2022年4月~2024年3月某院1 025例住院患者血培养阳性检出的病原菌及药敏试验资料,采用回顾性流行病学研究方法进行分析。结果 血流感染的病原菌主要是大肠埃希菌、肺炎克雷伯菌和金黄色葡萄球菌。耐甲氧西林金黄色葡萄球菌、耐碳青霉烯类大肠埃希菌和耐碳青霉烯类肺炎克雷伯菌感染患者的治疗仍然是临床的一个挑战。结论 该院应加强对重症监护室内耐甲氧西林金黄色葡萄球菌、耐碳青霉烯类大肠埃希菌和耐碳青霉烯类肺炎克雷伯菌感染患者的监测和感染防控。
A Study of the Pathogenic Bacterial Resistance and Risk Factors for Bloodstream Infections in Hospitalised Patients
OBJECTIVE The objective of this study is to analyse and discuss the drug resistance of pathogenic bacteria and the risk factors associated with bloodstream infections in patients admitted to a tertiary hospital in Guangzhou.METHODS A retrospective epidemiological study was conducted on data pertaining t0 1 025 inpatients of a hospital with positively detected pathogenic bacteria in blood culture and drug sensitivity tests.The data were collected from April 2022 to March 2024.RESULTS The most prevalent pathogens associated with bloodstream infections are Escherichia coli,Klebsiella pneumoniae,and Staphylococcus aureus.The continued existence of methicillin-resistant Staphylococcus aureus,carbapenem-resistant Escherichia coli,and carbapenem-resistant Klebsiella pneumoniae represents a significant therapeutic challenge.CONCLUSION It is recommended that hospitals implement enhanced surveillance and infection prevention and control measures for patients with methicillin-resistant Staphylococcus aureus,carbapenem-resistant Escherichia coli,and carbapenem-resistant Klebsiella pneumoniae infections in intensive care units.

bloodstream infectionbacterial pathogendrug resistancerisk factor

李子焕、黎聪荣、王恬、劳楚瑜

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广东省第二人民医院感染管理科,广东广州 510310

中山大学中山医学院生物安全实验室,广东广州 510080

中山大学附属第一医院药学部,广东广州 510080

血流感染 病原菌 耐药性 危险因素

2024

今日药学
广东省药学会 中国药学会

今日药学

影响因子:0.413
ISSN:1674-229X
年,卷(期):2024.34(9)