OBJECTIVE To investigate the inhibitoryeffect of puerarin on the lipopolysaccharide(LPS)-induced inflammatory response in THP-1(human monocytes).METHODS THP-1 cells were induced by LPS to activate theinflammatory response and then treated with puerarin.After that secretion of interleukin 1β(IL-1β),IL-6,tumor necrosis factor alpha(TNF-α)were detected using the ELISA method.RESULTS The secretion of IL-1β,IL-6,and TNF-α in inflammatory THP-1 cells was significantly reduced in the puerarin-treated groups(30-250 μmol·L-1)compared to the model group.CONCLUSION Puerarin can significantly reduce LPS-induced proinflammatory cytokine secretion in inflammatory THP-1 cells,therebylessening the severity of the inflammatory response.
维普
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