OBJECTIVE To assess the effect of ward-based clinical pharmacist interventions during the perioperative period in a trauma orthopedics department,and provide insights to enhance the rational use of antibiotics in clinical practice.METHODS A ward-based clinical pharmacist system was introduced in our hospital's trauma orthopedics department starting in October 2022.Patients undergoing surgical treatment within the clinical pathway of trauma orthopedics were selected for this study.The control group comprised patients from January 2022 to September 2022(n=322),while the observation group included patients from November 2022 to July 2023(n=445).Changes in Perioperative prophylactic medication-related evaluation indicators before and after the implementation were compared.RESULTS Patients in the observation group exhibited a statistically significant decrease in average hospitalization costs,average drug costs,average antibiotic drug costs,and average duration of antibiotic drug use by 27.60％,22.97％,87.64％,and 59.38％,respectively,compared to the control group(P＜0.01).The irrational use rate of antibiotics in the observation group significantly decreased to 4.72％compared to 44.10％in the control group(P＜0.01).Simultaneously,antibiotic use intensity decreased from 33.25 DDDs/(100 patient·days)to 7.97 DDDs/(100 patient·days).The postoperative surgical site infection rate also significantly decreased.CONCLUSION The implementation of ward-based pharmacists in pharmaceutical in clinical practices during the perioperative period of trauma orthopedics effectively promotes the rational use of antibiotics and reduces the medical burden on patients.
维普
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