Research progress on the novel anti-inflammatory free steroid compound vamorolone(VBP15)
Vamorolone is a novel anti-inflammatory drug with a structure similar to glucocorticoids.Related animal and clinical experiments on vamolodone have found that vamolodone has anti-inflammatory effects similar to prednisone in many animal disease models,but with significantly reduced side effects.Clinical studies have found that vamolodone has the same efficacy as glucocorticoids in Duchenne muscular dystrophy(DMD),but with a significantly improved safety profile and fewer adverse events,and vamolodone treatment does not cause corticosteroid-induced growth retardation.This article summarizes the progress of research on the structure and pharmacological effects of vamolodone,clinical trials and adverse effects,in order to provide more references for its clinical application.
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